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Carola Tilgmann

Driftchef

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Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats

Författare

  • Makoto Tsunoda
  • Jukka Tenhunen
  • Carola Tilgmann
  • Hiroyuki Arai
  • Kazuhiro Imai

Summary, in English

We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Here we examined the soluble (S-) and membrane-bound (MB-) COMT activities and COMT protein in the liver, kidney, and erythrocytes in both strains. Both the activities and the amounts of MB-COMT in the liver were lower in SHR than in WKY rats, but no such trend was found in the kidney or erythrocytes. Nor was such a trend observed in any of these three tissues for S-COMT. These results indicate that liver MB-COMT may be a relevant factor in blood pressure regulation in rats.

Publiceringsår

2003-11

Språk

Engelska

Sidor

923-927

Publikation/Tidskrift/Serie

Hypertension Research

Volym

26

Issue

11

Dokumenttyp

Artikel i tidskrift

Förlag

Nature Publishing Group

Nyckelord

  • Catechol-O-methyltransferase
  • Catecholamine
  • Liver
  • Membrane-bound

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0916-9636