Carola Tilgmann
Driftchef
Catechol-O-methyltransferase (COMT) in rat brain : immunoelectron microscopic study with an antiserum against rat recombinant COMT protein
Författare
Summary, in English
Localization of catechol-O-methyltransferase (COMT) in rat cerebral cortex, neostriatum and cerebellar cortex was studied with pre-embedding immunoelectron microscopy using a specific antiserum raised against rat recombinant COMT protein. In all areas, immunoreactivity was found both in astrocytes and in neuronal processes. Reaction product was seen in the cytoplasm and in association with tubular structures of dendritic processes. Immunoreactivity was also located postsynaptically in dendritic spines and associated with the postsynaptic membrane. Strong immunoreaction was also seen in the cytoplasm of ependymal cells lining the ventricles, and in tanycytes in median eminence. The results suggest that postsynaptic dendritic spines and astrocytic processes may be the sites of catecholamine inactivation by COMT in rat brain.
Publiceringsår
1995-02-24
Språk
Engelska
Sidor
57-60
Publikation/Tidskrift/Serie
Neuroscience Letters
Volym
187
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Nyckelord
- Astrocytes
- Catecholamine
- Cerebellum
- Cortex
- Postsynaptic
- Striatum
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0304-3940