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Carola Tilgmann

Driftchef

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Catechol-O-methyltransferase (COMT) in rat brain : immunoelectron microscopic study with an antiserum against rat recombinant COMT protein

Författare

  • Tuula Karhunen
  • Carola Tilgmann
  • Ismo Ulmanen
  • Pertti Panul

Summary, in English

Localization of catechol-O-methyltransferase (COMT) in rat cerebral cortex, neostriatum and cerebellar cortex was studied with pre-embedding immunoelectron microscopy using a specific antiserum raised against rat recombinant COMT protein. In all areas, immunoreactivity was found both in astrocytes and in neuronal processes. Reaction product was seen in the cytoplasm and in association with tubular structures of dendritic processes. Immunoreactivity was also located postsynaptically in dendritic spines and associated with the postsynaptic membrane. Strong immunoreaction was also seen in the cytoplasm of ependymal cells lining the ventricles, and in tanycytes in median eminence. The results suggest that postsynaptic dendritic spines and astrocytic processes may be the sites of catecholamine inactivation by COMT in rat brain.

Publiceringsår

1995-02-24

Språk

Engelska

Sidor

57-60

Publikation/Tidskrift/Serie

Neuroscience Letters

Volym

187

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Nyckelord

  • Astrocytes
  • Catecholamine
  • Cerebellum
  • Cortex
  • Postsynaptic
  • Striatum

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0304-3940