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Carola Tilgmann

Driftchef

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O-methylation of L-dopa in melanin metabolism and the presence of catechol-O-methyltransferase in melanocytes.

Författare

  • N. Smit
  • C. Tilgmann
  • T. Karhunen
  • R. Slingerland
  • I. Ulmanen
  • W. Westerhof
  • S. Pavel

Summary, in English

O-Methylation of L-dopa was investigated as a possible regulatory mechanism in melanin metabolism. The methylation product of L-dopa, 3-O-methoxytyrosine was detected in extracts of cultured human melanocytes. The enzyme catechol-O-methyltransferase is responsible for this O-methylation and that of the dihydroxyindolic intermediates of melanogenesis. The enzyme is present in melanocytes in its soluble and membrane-bound isoforms. Immuno-electron microscopy suggests the presence of the membrane-bound enzyme in the endoplasmic reticulum. This localization may indicate a role of catechol-O-methyltransferase in protecting the melanocyte against reactive dihydroxyphenolic intermediates of melanogenesis leaking from the melanogenic compartments. On the other hand, the O-methylation of L-dopa may serve as a regulatory point in melanogenesis during early stage of tyrosinase processing in the endoplasmic reticulum.

Publiceringsår

1994-12

Språk

Engelska

Sidor

403-408

Publikation/Tidskrift/Serie

Pigment Cell Research

Volym

7

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0893-5785