Carola Tilgmann
Driftchef
Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)
Other contributions
- Piero Pollesello
- Martti Ovaska
- J. Tenhunen
- J. Vidgren
- Marjo Yliperttula
- Carola Tilgmann
- T. Lotta
- Juha Kaivola
Summary, in English
This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms. The invention also relates to phospholamban inhibiting compounds with certain structural, physicochemical and spatial characteristics that allow for the interaction of said compounds with specific residues of the active site of phospholamban
Publiceringsår
2004-08-10
Språk
Engelska
Dokumenttyp
Patent
Ämne
- Cardiac and Cardiovascular Systems
- Pharmaceutical Chemistry
Nyckelord
- calcium-ATPase
- phospholamban
- drug discovery
Status
Published